Following months of continuous fat-loss based nutrition and intense training to meet your weight loss goals, you’ve now made remarkable improvements with your physique. You feel encouraged about your progress but you know there is more work ahead. However, you still have a nagging problem: that pesky film of body fat that resides in the corners of your lower back region (e.g. love handles) and bottom of your abdominals. This is the stage where AMMOHEAT™ Thermogenic Weight Loss Gel can forge a break through with your physique and results*.

*Results may vary. Weight loss results can differ depending on the individual. Proper diet, a healthy lifestyle, and exercise are required to achieve the desired results using this product.

THE SCIENCE

By infusing Alpha-2 enriched areas with Capsaicin and Glycyrrhizinic Acid, this antagonizes (blocks) A2 adrenergic receptors, assisting in the release norepinephrine (which helps form lipolysis). The increased blood flow to fatty areas, with Capsaicin and Glycyrrhizinic Acid, produces fatty acid oxidation. This means, you’ll have free fatty acids in the blood stream, ready to be used as energy. However, the real star of the show is Glycyrrhizinic Acid. Cortisol is secreted in response to stress leading to fat storage beneath the skin, thereby encouraging cellulite. Glycyrrhizinic Acid, a compound derived from licorice, fights this reaction making it a favorable candidate for cellulite therapy.

The actionable mechanism of Gycyrrhetinic Acid within our topical application is helping to reduce fat. Cortisol, which is involved in the distribution and deposition of fat, is regulated by an enzyme called 11-beta-hydroxysteroid dehydrogenase. Decio Armanini M.D., a Professor of Endocrinology at the University of Padua in Italy, affirmed that “Glycyrrhizinic Acid, the active principal of licorice root, blocked 11-beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes”. This groundbreaking study by Dr. Armanini’s group revealed a promising outcome from topical applications of a cream containing Gycyrrhetinic Acid: the reduction of thigh fat thickness as measured by ultrasound.

Eighteen healthy young women, 20 to 33 years old and of normal weight, were randomly assigned to apply a cream containing Glycyrrhizinic Acid or placebo to one thigh. After one month of treatment with Glycyrrhizinic Acid cream, both the circumference and the thickness of the superficial fat layer were reduced compared with the opposite, untreated thigh, and also compared with the placebo group. Both comparisons were statistically significant. In women treated with Glycyrrhizinic Acid cream, the thickness of the superficial fat layer showed measurable decreases.

THE FIRST PIECE: CAPSAICIN

Previous studies revealed that transient receptor potential vanilloid 1(TRPV1) channels take part in weight loss by enhancing intracellular Ca2+ levels. However, the potential mechanism of the effects of dietary Capsaicin on obesity is still not completely understood. Ca2+ transfer induced by connexin43 (Cx43) molecules, between coupled cells, takes part in adipocyte differentiation. Whether TRPV1-evoked alterations in Cx43-mediated adipocyte-to-adipocyte communications, playing a role in obesity is still unknown. TRPV1 and Cx43 co-expressed in mesenteric adipose tissue. TRPV1 activation by Capsaicin increased the influx of Ca2+ in 3T3-L1 preadipocytes, promoting cell lipolysis. These effects were deficient when capsazepine, a TRPV1 antagonist, and (Glycyrrhizinic Acid) (18α-GA), a gap-junction inhibitor, were administered.

Long-term chronic dietary Capsaicin reduced the weights of perirenal, mesenteric and adipose tissues (e.g. fat-loss) in WT mice fed a high-fat diet. Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARδ and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of Capsaicin were absent in TRPV1-/- mice. Long-term chronic dietary Capsaicin (decreased the body weights) and serum lipids of WT mice, but not TRPV1-/- mice, fed a high-fat diet.

CAPSAICIN AND GLYCYRRHIZINIC ACID | QUANTIFIABLE FAT-LOSS

This study demonstrated that Capsaicin activation of TRPV1-evoked increased Ca2+ influx in Cx43-mediated adipocyte-to-adipocyte communication, promoting lipolysis (fat-loss) in both vitro and vivo. TRPV1 activation by dietary Capsaicin improved visceral fat remodeling through the up-regulation of Cx43.

Now let’s focus again on Glycyrrhizinic Acid in the reduction of body fat mass. 15 normal-weight subjects were studied (7 males, age 22–56 yr., and 8 females, age 21–56 yr.), who specially prepared the application for 2 months topically, once a day, consisting of a commercial preparation of Glycyrrhizinic Acid. Body fat mass (BFM, expressed as a percentage of total body weight, by skinfold thickness and by bioelectrical impedance analysis, BIA) and extracellular water (ECW, percentage of total body water, by BIA) were measured. However, body mass index (BMI) did not change but ECW increased. BFM was reduced by Glycyrrhizinic Acid and plasma renin activity (PRA) and aldosterone were suppressed. Glycyrrhizinic Acid was able to reduce body fat mass and suppress aldosterone, without any change in BMI.

Since the subjects were consuming the same amount of calories during the study, it can be scientifically suggested that Glycyrrhizinic Acid can reduce fat by inhibiting 11β-hydroxysteroid dehydrogenase Type 1 at the level of fat cells.

CONCLUSION

AMMOHEAT™ Weight Loss Gel is a scientifically designed thermal insulator, leveraging a proprietary blend of functional raw materials, formulated using ratios and exclusive delivery systems. The product then traps the heat from escaping the skin, thus resulting in the best sweat of your life. However, you also acquire the principal thermogenic weight loss benefits from the synergy of Glycyrrhizinic Acid and Capsaicin in this non-stimulant driven, topical weight loss system*.

*Results may vary. Weight loss results can differ depending on the individual. Proper diet, a healthy lifestyle, and exercise are required to achieve the desired results using this product.